You can sort GitHub issues by most “upvoted” using this syntax:

is:issue is:open sort:reactions-+1-desc

Thanks to gromenauer for making me aware of it in this GitHub comment.

Full documentation for sorting GitHub issues and pull requests can be found here.

EDIT (2024-08-27T05:20Z): There are also UI options that enable sorting by most “upvoted”:

  • On desktop (through a web browser):

  • On mobile (through the app):